Package: renz 0.2.1

renz: R-Enzymology

Contains utilities for the analysis of Michaelian kinetic data. Beside the classical linearization methods (Lineweaver-Burk, Eadie-Hofstee, Hanes-Woolf and Eisenthal-Cornish-Bowden), features include the ability to carry out weighted regression analysis that, in most cases, substantially improves the estimation of kinetic parameters (Aledo (2021) <doi:10.1002/bmb.21522>). To avoid data transformation and the potential biases introduced by them, the package also offers functions to directly fitting data to the Michaelis-Menten equation, either using ([S], v) or (time, [S]) data. Utilities to simulate substrate progress-curves (making use of the Lambert W function) are also provided. The package is accompanied of vignettes that aim to orientate the user in the choice of the most suitable method to estimate the kinetic parameter of an Michaelian enzyme.

Authors:Juan Carlos Aledo

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renz.pdf |renz.html
renz/json (API)
NEWS

# Install 'renz' in R:
install.packages('renz', repos = c('https://jcaledo.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Datasets:
  • ONPG - Kinetic data for the hydrolysis of ONPG catalyzed by Beta-galactosidase
  • TcTS - Kinetic data for Trypanosoma cruzi trans-sialidase.
  • hk - Kinetic data for the phosphorylation of glucose catalyzed by hexokinase.

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

3.78 score 24 scripts 218 downloads 9 exports 1 dependencies

Last updated 12 months agofrom:baea88b5b1. Checks:OK: 7. Indexed: yes.

TargetResultDate
Doc / VignettesOKNov 22 2024
R-4.5-winOKNov 22 2024
R-4.5-linuxOKNov 22 2024
R-4.4-winOKNov 22 2024
R-4.4-macOKNov 22 2024
R-4.3-winOKNov 22 2024
R-4.3-macOKNov 22 2024

Exports:bibidir.MMecbehfE.progresshwint.MMlbsE.progress

Dependencies:VGAM

Enzyme Kinetic Parameters

Rendered fromKm_Vm.Rmdusingknitr::rmarkdownon Nov 22 2024.

Last update: 2021-12-02
Started: 2021-12-02

Fitting the Michaelis-Menten Model

Rendered fromdirMM.Rmdusingknitr::rmarkdownon Nov 22 2024.

Last update: 2023-11-28
Started: 2021-12-02

Integrated Michaelis-Menten Equation

Rendered fromintMM.Rmdusingknitr::rmarkdownon Nov 22 2024.

Last update: 2021-12-02
Started: 2021-12-02

Linearized Michaelis-Menten Equations

Rendered fromLinearized_MM.Rmdusingknitr::rmarkdownon Nov 22 2024.

Last update: 2021-12-02
Started: 2021-12-02

Michaelis-Menten and the Lambert W function

Rendered fromLambert.Rmdusingknitr::rmarkdownon Nov 22 2024.

Last update: 2023-11-28
Started: 2021-12-02