{ "_id": "6a25438f4b233be19839a4dd", "Package": "renz", "Type": "Package", "Title": "R-Enzymology", "Version": "0.2.1", "Author": "Juan Carlos Aledo", "Maintainer": "Juan Carlos Aledo ", "Description": "Contains utilities for the analysis of Michaelian kinetic\ndata. Beside the classical linearization methods\n(Lineweaver-Burk, Eadie-Hofstee, Hanes-Woolf and\nEisenthal-Cornish-Bowden), features include the ability to\ncarry out weighted regression analysis that, in most cases,\nsubstantially improves the estimation of kinetic parameters\n(Aledo (2021) ). To avoid data\ntransformation and the potential biases introduced by them, the\npackage also offers functions to directly fitting data to the\nMichaelis-Menten equation, either using ([S], v) or (time, [S])\ndata. Utilities to simulate substrate progress-curves (making\nuse of the Lambert W function) are also provided. The package\nis accompanied of vignettes that aim to orientate the user in\nthe choice of the most suitable method to estimate the kinetic\nparameter of an Michaelian enzyme.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "LazyData": "true", "RoxygenNote": "7.2.3", "VignetteBuilder": "knitr", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-07 10:07:29 UTC", "User": "root" }, "Repository": "https://jcaledo.r-universe.dev", "Date/Publication": "2023-11-28 02:40:54 UTC", "RemoteUrl": "https://github.com/cran/renz", "RemoteRef": "HEAD", "RemoteSha": "baea88b5b1e214391057958f56e31278d2d66d23", "MD5sum": "ae2815dd4ebcaaa8a7a87724aed4b13c", "_user": "jcaledo", "_type": "src", "_file": "renz_0.2.1.tar.gz", "_fileid": "01e2d57aa8d560245971141da9d6e911fda5f56c8a327f7dd04dfe9f75cdef82", "_filesize": 1972159, "_sha256": "01e2d57aa8d560245971141da9d6e911fda5f56c8a327f7dd04dfe9f75cdef82", "_created": "2026-06-07T10:07:29.000Z", "_published": "2026-06-07T10:10:23.025Z", "_distro": "noble", "_jobs": [ { "job": 79950275137, "time": 123, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7463117947" }, { "job": 79950275128, "time": 122, "config": "linux-release-x86_64", "r": "4.6.0", "check": "OK", "artifact": "7463117600" }, { "job": 79950275150, "time": 126, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "7463116385" }, { "job": 79950275133, "time": 118, "config": "macos-release-arm64", "r": "4.6.0", "check": "OK", "artifact": "7463114874" }, { "job": 79950057728, "time": 206, "config": "source", "r": "4.6.0", "check": "OK", "artifact": "7463102305" }, { "job": 79950275136, "time": 96, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "7463114652" }, { "job": 79950275163, "time": 96, "config": "windows-devel", "r": "4.7.0", "check": "OK", "artifact": "7463114747" }, { "job": 79950275167, "time": 100, "config": "windows-oldrel", "r": "4.5.3", "check": "OK", "artifact": "7463115090" }, { "job": 79950275172, "time": 86, "config": "windows-release", "r": "4.6.0", "check": "OK", "artifact": "7463113258" } ], "_buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989", "_status": "success", "_host": "GitHub-Actions", "_upstream": "https://github.com/cran/renz", "_commit": { "id": "baea88b5b1e214391057958f56e31278d2d66d23", "author": "Juan Carlos Aledo ", "committer": "cran-robot ", "message": "version 0.2.1\n", "time": 1701139254 }, "_maintainer": { "name": "Juan Carlos Aledo", "email": "caledo@uma.es", "login": "jcaledo", "description": "", "uuid": 10573051 }, "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.0.0", "role": "Depends" }, { "package": "graphics", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "VGAM", "role": "Imports" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "testthat", "role": "Suggests" } ], "_owner": "cran", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_contributors": [ { "user": "jcaledo", "count": 2, "uuid": 10573051 } ], "_userbio": { "uuid": 10573051, "type": "user", "name": "Juan Carlos Aledo" }, "_downloads": { "count": 155, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/renz" }, "_searchresults": 59, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "extra/renz.html", "manual.pdf" ], "_realowner": "jcaledo", "_cranurl": false, "_releases": [ { "version": "0.1.1", "date": "2021-12-02" }, { "version": "0.2.1", "date": "2023-11-27" } ], "_exports": [ "bibi", "dir.MM", "ecb", "eh", "fE.progress", "hw", "int.MM", "lb", "sE.progress" ], "_datasets": [ { "name": "hk", "title": "Kinetic data for the phosphorylation of glucose catalyzed by hexokinase.", "object": "hk", "class": [ "data.frame" ], "fields": [ "a", "b", "rate" ], "rows": 25, "table": true, "tojson": true }, { "name": "ONPG", "title": "Kinetic data for the hydrolysis of ONPG catalyzed by Beta-galactosidase (EC. 3.2.1.23)", "object": "ONPG", "class": [ "data.frame" ], "fields": [ "ONPG", "v1", "v2", "v3", "v4", "v5", "v6", "v7", "v8" ], "rows": 10, "table": true, "tojson": true }, { "name": "TcTS", "title": "Kinetic data for Trypanosoma cruzi trans-sialidase.", "object": "TcTS", "class": [ "data.frame" ], "fields": [ "a", "b", "rate" ], "rows": 16, "table": true, "tojson": true } ], "_help": [ { "page": "bibi", "title": "Kinetic Mechanisms and Parameters for Bi-Bi Reactions", "topics": [ "bibi" ] }, { "page": "dir.MM", "title": "Non-linear Least-squares Fitting of the MM equation", "topics": [ "dir.MM" ] }, { "page": "ecb", "title": "Eisenthal & Cornish-Bowden", "topics": [ "ecb" ] }, { "page": "eh", "title": "Eadie-Hofstee Transformation", "topics": [ "eh" ] }, { "page": "fE.progress", "title": "Fitted Progress Curve for Enzyme-Catalyzed Reaction", "topics": [ "fE.progress" ] }, { "page": "hk", "title": "Kinetic data for the phosphorylation of glucose catalyzed by hexokinase.", "topics": [ "hk" ] }, { "page": "hw", "title": "Hanes-Woolf Transformation", "topics": [ "hw" ] }, { "page": "int.MM", "title": "Linearization of The Integrated Michaelis-Menten Equation", "topics": [ "int.MM" ] }, { "page": "lb", "title": "Lineweaver-Burk Transformation", "topics": [ "lb" ] }, { "page": "ONPG", "title": "Kinetic data for the hydrolysis of ONPG catalyzed by Beta-galactosidase (EC. 3.2.1.23)", "topics": [ "ONPG" ] }, { "page": "sE.progress", "title": "Progress Curve for Enzyme-Catalyzed Reaction", "topics": [ "sE.progress" ] }, { "page": "TcTS", "title": "Kinetic data for Trypanosoma cruzi trans-sialidase.", "topics": [ "TcTS" ] } ], "_readme": "https://github.com/cran/renz/raw/HEAD/README.md", "_rundeps": [ "VGAM" ], "_vignettes": [ { "source": "Km_Vm.Rmd", "filename": "Km_Vm.html", "title": "Enzyme Kinetic Parameters", "engine": "knitr::rmarkdown", "headings": [ "Introduction" ], "created": "2021-12-02 12:50:02", "modified": "2021-12-02 12:50:02", "commits": 1 }, { "source": "dirMM.Rmd", "filename": "dirMM.html", "title": "Fitting the Michaelis-Menten Model", "engine": "knitr::rmarkdown", "headings": [ "Non-linear least square", "Loading some real kinetic data", "First thing first: scatter plot", "Direct Michaelis-Menten fitting" ], "created": "2021-12-02 12:50:02", "modified": "2023-11-28 02:40:54", "commits": 2 }, { "source": "intMM.Rmd", "filename": "intMM.html", "title": "Integrated Michaelis-Menten Equation", "engine": "knitr::rmarkdown", "headings": [ "How many progress-curves do we need to estimate $K_m$ and $V_{max}$?", "Integrating the Michaelis-Menten equation", "Some final considerations" ], "created": "2021-12-02 12:50:02", "modified": "2021-12-02 12:50:02", "commits": 1 }, { "source": "Linearized_MM.Rmd", "filename": "Linearized_MM.html", "title": "Linearized Michaelis-Menten Equations", "engine": "knitr::rmarkdown", "headings": [ "Loading kinetic data", "First thing first: scatter plot", "Linearizing the Michaelis-Menten equation", "Lineweaver-Burk", "Hanes-Woolf", "Eadie-Hofstee", "Eisenthal & Cornish-Bowden" ], "created": "2021-12-02 12:50:02", "modified": "2021-12-02 12:50:02", "commits": 1 }, { "source": "Lambert.Rmd", "filename": "Lambert.html", "title": "Michaelis-Menten and the Lambert W function", "engine": "knitr::rmarkdown", "headings": [ "Stating the problem we want to solve", "The integrated Michaelis-Menten", "The Lambert W function", "Fitting the progress curve for enzyme-catalyzed reactions" ], "created": "2021-12-02 12:50:02", "modified": "2023-11-28 02:40:54", "commits": 2 } ], "_score": 4.168792020314182, "_indexed": true, "_nocasepkg": "renz", "_universes": [ "jcaledo" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.2.1", "date": "2026-06-07T10:09:49.000Z", "distro": "noble", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "0cf41dda83621cc534fbf70009c4b4d4c7c96ada39a9e73ea30799129a004a0f", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.6.0", "os": "linux", "version": "0.2.1", "date": "2026-06-07T10:09:48.000Z", "distro": "noble", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "6f4146f5d2afbf05e7769e074c95319ee9337296186bc023b4886a758e0ce8b1", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.5.3", "os": "mac", "version": "0.2.1", "date": "2026-06-07T10:09:43.000Z", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "fbcd48bc113de557be6f4db19f1ac10c949bf25d1a9057003c177101f6defae2", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.6.0", "os": "mac", "version": "0.2.1", "date": "2026-06-07T10:09:31.000Z", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "a445a61262997cf31d9713ed74267cb4250877623693ce1380947f6a0556f57d", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.6.0", "os": "wasm", "version": "0.2.1", "date": "2026-06-07T10:09:39.000Z", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "98306dd496dd9eaac2ad9261a9cca3d2e3b1b91831140c7486ed1a18bc8a969c", "status": "success", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.7.0", "os": "win", "version": "0.2.1", "date": "2026-06-07T10:09:18.000Z", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "10ea78c29c4bf40ae553e597b56b8fadbe2cba1af0521f724f1b5e4678f41d29", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.5.3", "os": "win", "version": "0.2.1", "date": "2026-06-07T10:09:20.000Z", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "016e37e7015b05df950f838be398d8baf6db1db8d40d903a79842fb9da5fdabb", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" }, { "r": "4.6.0", "os": "win", "version": "0.2.1", "date": "2026-06-07T10:09:05.000Z", "commit": "baea88b5b1e214391057958f56e31278d2d66d23", "fileid": "a190da9908f0de3c0d266209d0653e1957eaf5c35d074da93df3ba6f1e7e849e", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/jcaledo/actions/runs/27089409989" } ] }